- Eating problem
- Ear infection and hearing loss
- Speech problem
- Dental problem
- Nose deformity
For development of an orofacial cleft include:
- Genetics
- Environmental agents such as secondhand exposure to smoke
- Medications such as phenytoin, sodium valproate, topiramate, and methotrexate
- Smoking and using tobacco products
- Alcohol
- Folate deficiency
- Maternal obesity
- Diabetes diagnosed before pregnancy is a more significant risk factor than gestational diabetes.




