This is needed for diagnosis of inherited hemoglobin disorders, inform errors of metabolism, baryotyping, fetal viral infection, Rh, disease, uexplained hydrops and fetal anemia. The aspiration of fetal blood is usally under taken from the umbilical cord around 18 weeks. While preparing the patient for procedure counseling is needed about the risks of fetal loss, trauma, bloodloss, preterm rapitune of membaren sensitization DNA screening for any specific disease may require both direct indirect methods. This procedure is easy when placounta is anterior there is no need of fetal sedation.