In most cases, it's caused by loss of the nerve cells that control the swallowing muscles in the esophagus. Don’t yet know why these nerve cells are lost. In rare cases, achalasia is caused by a tumor.
Achalasia can occur at any age. But it happens most often between ages 30 and 60. Men and women are equally at Risk. Risk factors may include:
- Having certain genes
- Having a problem with immune system that Causes it to attack nerve cells in esophagus
- Having herpes simplex virus or other viral infections
- Having Chagas disease. This is an infection caused by a parasite. The parasite is passed to people through the bite of an insect. Chagas disease is mainly found in poor rural areas of Mexico and Central and South America.
Symptoms can occur a bit differently in each person. They develop over time as the esophagus becomes wider and weaker. Symptoms can include:
- Trouble swallowing food (dysphagia)
- Food or liquid flowing back up into throat (regurgitation)
- Waking up at night coughing or choking due to regurgitation
- Heartburn
- Chest pain or pressure
- Trouble burping
- Hiccups
- Weight loss
Treatment can help prevent long-term Complications such as:
- Aspiration pneumonia. This is caused when food or liquids in esophagus back up into throat and breathe them into lungs.
- Esophageal perforation. This is a hole in the esophagus. It may happen if the walls of esophagus become weak and bulge. It may also happen during Treatment. Esophageal perforation may cause a life-threatening infection.
- Esophageal cancer. People with achalasia are at higher Risk for this type of cancer.
No evidence available in Research how to prevent achalasia.




